Overdosis Loperamide Imodium, suatu obat antidiare (mohon aktifkan subtitle)

In this video, I dissect the medical science behind the Japanese Drama "Midori, unsung Cinderella", Episode 2. There is a patient with cancer and had diarrhea as a side effect of chemotherapy. The doctor prescribes loperamide. However, the patient took the drug inappropriate dose, causing loperamide toxicity. What is loperamide, how is its action, how is the patient saved from this critical event, and what is the mechanism of its toxicity, all are discussed here.

Segments:
00:00 Intro
00:39 Unsung Cinderella: Midori, the hospital pharmacist
01:46 What is loperamide: Indications, mechanism of action, directions for use
04:09 Loperamide medicinal chemistry
09:16 Loperamide overdose
10:22 FDA warning box
11:15 Symptoms of general toxicity
11:49 Mechanism of loperamide toxicity
13:50 Management of loperamide overdose
15:22 Bonus: chemotherapy-induced diarrhea