Drugs used in treatment of cough - Quick review Neet pg and Fmge by Dr Rajesh Gubba

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Symptomatic treatment of a cough

Productive cough
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Drugs to decrease the viscosity of mucus and enhance mucociliary clearance (no cough suppression)
Expectorants (e.g., guaifenesin)
Loosen mucus by increasing the fluid content of bronchial secretions via an unknown mechanism
Should be taken with sufficient amount of water for the best effect
Mucolytics (e.g., N-acetylcysteine)
Decrease the viscosity of mucus by disrupting disulfide bonds of mucus glycoproteins
Used in patients with viscous mucus in chronic bronchopulmonary diseases (e.g., cystic fibrosis, COPD)
Also used as an antidote in acetaminophen poisoning
Chest physiotherapy
Chest percussion/vibration may be used with postural drainage to mobilize and enhance the clearance of mucus from the airway.
Indicated in patients with thick mucus and/or ineffective cough (e.g., cystic fibrosis, bronchiectasis, pneumonia)

Non-productive cough: cough suppressants (antitussive medications)
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Centrally acting cough suppressants
Examples: dextromethorphan, codeine
See opioids for more information
Peripherally acting cough suppressants (e.g., benzonatate)

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